• Claudia Maria Costa Oliveira, Paula Sátiro Timbó, Sanna Roque Pinheiro, Janaína Gonçalves Silva Leite, Luciana Sátiro Timbó, and Ronaldo Matos Esmeraldo.
• Faculdade de Medicina Christus, FortalezaCeará, Brazil.
• Sao Paulo Med J. 2013 Jan 1; 131 (6): 369376369-76.

Context And ObjectiveThe prevalence of post-renal transplant anemia (PTA) reported in the literature is variable and several factors contribute towards its pathophysiology. This study aimed to investigate the prevalence of PTA, its associated risk factors and the impact of therapy without steroids.Design And SettingRetrospective cohort study in a renal transplantation unit at a tertiary hospital.MethodsAnemia was defined as hemoglobin (Hb) < 12 g/dl in female adult recipients and < 13 g/dl in males. Donor and recipient age and gender, type of donor, creatinine, delayed graft function, acute rejection, use of angiotensin-converting enzyme inhibitors (ACEI) or angiotensin receptor blockers (ARB) and therapy without steroids were investigated as risk factors for PTA through multivariate logistical regression analysis.ResultsEvaluations were performed on 258 recipients (mean age: 38.8 years; 60.5% males; 35.7% did not receive steroids). Anemia was diagnosed in 38% of the patients (at the sixth month, M6), 28% (M12), 32% (M24) and 45% (at last follow up). Donor age > 50 years was associated with greater risks of PTA at M6 (odds ratio (OR) = 4.68) and M24 (OR = 6.57), as well as with therapy without steroids at M6 (OR = 2.96). Delayed graft function was independently associated with PTA at M6 (OR = 3.66) and M12 (OR = 2.85).ConclusionThe lowest prevalence of PTA was observed between M9 and M24 after renal transplantation. Delayed graft function, donor age and therapy without steroids were the most important factors associated with PTA.

30 keywords...

hide…