• Am J Manag Care · Feb 2024

    Real-world users of triple therapy for asthma in the US.

    • Nadia N Hansel, Carl B Abbott, Carlyne M Averell, Guillaume Germain, François Laliberté, Malena Mahendran, Mei S Duh, and Russell A Settipane.
    • GSK, 5 Moore Dr, Research Triangle Park, NC 27709. Email: cmaverell@gmail.com.
    • Am J Manag Care. 2024 Feb 1; 30 (2): 748174-81.

    ObjectivesFor patients with asthma who remain symptomatic on a medium-dose inhaled corticosteroid/long-acting β2 agonist, addition of a long-acting muscarinic antagonist as a supplementary controller is a recommended option. However, real-world data on the characteristics and treatment patterns of these patients are limited. This study described the demographics and clinical characteristics of new users of single- or multiple-inhaler triple therapy and treatment patterns preceding triple-therapy initiation.Study DesignThis retrospective cohort study used medical and pharmacy claims data from the IQVIA PharMetrics Plus database.MethodsThe study population comprised adults with asthma with or without chronic obstructive pulmonary disease (COPD) initiating triple therapy with single-inhaler fluticasone furoate/umeclidinium/vilanterol (FF/UMEC/VI; 100/62.5/25 μg) or multiple-inhaler triple therapy (MITT) between September 18, 2017, and September 30, 2019. Demographics, clinical characteristics, and treatment patterns in the 12 months preceding triple-therapy initiation were described (baseline period).ResultsA total of 12,395 patients were included. Among FF/UMEC/VI initiators with asthma (n = 1301), the mean age was 49.0 years and 59.3% were women. During the baseline period, 81.5% of patients used controller therapy, 94.7% used rescue medications, and 42.0% reported at least 1 asthma-related exacerbation; the annual mean exacerbation rate was 0.96. Similar trends were observed among patients with asthma initiating MITT and patients with comorbid asthma-COPD initiating FF/UMEC/VI or MITT.ConclusionIn real-world practice, triple therapy is often utilized following other asthma controller medication use. High disease burden, as evidenced by substantial use of rescue medications and continued asthma-related exacerbations, suggests that patients may not have achieved adequate asthma control prior to triple-therapy initiation.

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