• Bratisl Med J · Jan 2024

    Characterization of HIV-1 subtypes and drug resistance mutations in Slovakia: update 2017-2018.

    • Monika Habekova, Danica Valkovicova Stanekova, Maria Takacova, and Alexandra Kovarova.
    • Bratisl Med J. 2024 Jan 1; 125 (3): 166171166-171.

    ObjectivesThis study aimed to provide an overview on the HIV-1 subtypes circulating in Slovakia between 2017 and 2018 and to evaluate the risk of transmission of HIV‑resistant strains.BackgroundThe HIV epidemic in Slovakia is characterised by low incidence of new and pre-existing infections and a slightly elevated level of strain heterogeneity.MethodsPartial HIV pol gene sequences of 110 individuals newly diagnosed with HIV between 2017 and 2018 were analysed.ResultsThe genotypic analysis revealed sporadic occurrence of mutations linked to HIV resistance to antiretroviral therapy (ART). The HIV-1 B subtype has been found as predominant (84.55 %) and primarily linked to men who have sex with men (MSM). A total of eighteen individuals (15.45 %) were found to be infected with HIV-1 non-B subtypes.ConclusionThe data suggest a minimal risk of a resistant HIV strain transmission and a marginal rise of HIV-1 subtypes´ diversity. The HIV-1 B subtype remains the most prevalent in the period 2017-2018 in Slovakia (Tab. 2, Fig. 2, Ref. 37).

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