• Kai-Chieh Chang, Sin-Yi Huang, Wen-Hsin Tsai, Hao-Wen Liu, Jia-Sin Liu, Chia-Lin Wu, and Ko-Lin Kuo.
• Division of Nephrology, Department of Internal Medicine, Changhua Christian Hospital, Changhua, Taiwan, ROC.
• J Chin Med Assoc. 2024 Apr 1; 87 (4): 393399393-399.

BackgroundVegetarian diets have been shown to lower the risks of hyperuricemia and gout. Little is known about the risk factors of hyperuricemia in vegetarians.MethodsThis community-based retrospective case-control study was conducted to establish prediction models for hyperuricemia. From September 5, 2005, to December 31, 2016, 7331 adult vegetarians were recruited at Taipei Tzu Chi Hospital. Hyperuricemia was defined as a serum uric acid concentration greater than 7 mg/dL.ResultsThere were 593 (8.1%) vegetarians with hyperuricemia and 6738 (91.9%) without hyperuricemia. We stepwise built up three models for predicting hyperuricemia in vegetarians. The full model (model 3) has the highest area under the receiver operating characteristic curve (AUROC, 85.52%). Additionally, the AUROC of model 3 is 77.97% and 84.85% in vegetarians with or without prior gout history, respectively. Moreover, male gender, hyperlipidemia, body mass index, and serum albumin are independent risk factors for hyperuricemia in vegetarians. In contrast, estimated glomerular filtration rate and proteinuria are independently associated with lower risks of hyperuricemia in vegetarians.ConclusionOur study revealed that risk factors for hyperuricemia, which includes clinical characteristics, account for more than 85% of discriminatory performance in Taiwanese vegetarians. This model may be helpful for monitoring and preventing hyperuricemia in the population.Copyright © 2024, the Chinese Medical Association.

21 keywords...

hide…