• Juan José Valenzuela-Fuenzalida, Daniela Martínez Hernández, Daniel Milos-Brandenberg, Zmilovan Koscina, Roberto Avila-Sepulveda, Belen Baez, Daniela Perez-Jimenez, Pablo Nova Baeza, Mathias Orellana Donoso, and Alejandro Bruna-Mejias.
• Department of Morphology and Function, Faculty of Health and Social Sciences, Universidad de las Américas, Santiago, Chile.
• Medicine (Baltimore). 2024 Feb 23; 103 (8): e37093e37093.

BackgroundSitus inversus is a rare congenital anatomical variant that involves a group of anomalies regarding the arrangement of intrathoracic and intraabdominal organs. Being able to find in the abdominal region the liver, gallbladder, inferior vena cava, and head of the pancreas and ascending colon on the left side of the abdomen, while on the right side there is the spleen, the stomach, the body of the pancreas, the ligament of Treitz, descending colon among others. In this same way, the thoracic organs, lungs and heart, are changed in their position in a mirror translocation.MethodsWe systematically searched MEDLINE, Web of Science, Google Scholar, CINAHL, Scopus, and LILACS; the search strategy included a combination of the following terms: "Situs inversus," "Situs inversus totalis," "Cancer," "Neoplasm," "Abdominopelvic regions," and "clinical anatomy."ResultsWithin the 41 included studies, 46 patients with situs inversus who had cancer, in addition to being found in this organ and in these regions, we also found as a result that the majority of the studies in the research were in stage II; finally, no one study could assert the direct relationship between the situs inversus totalis and the cancer.ConclusionIf our hallmarks could make us think that more exhaustive follow-up of the stomach and other organs should be carried out in these patients, there could also be other predisposing factors for cancer, which is why more studies are suggested to give future diagnostic and treatment guidelines treatment.Copyright © 2024 the Author(s). Published by Wolters Kluwer Health, Inc.

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