• Hamdah Bashir Mughal, Ayesha Isani Majeed, Maria Aftab, Muhammad Furqan Ubaid, Sabahat Zahra, AbbasiMuhammad Sajid RafiqMSRDepartment of Nephrology, Pakistan Institute of Medical Sciences, Islamabad, Pakistan., Mamoon Qadir, Mumtaz Ahmad, Amna Akbar, Sabahat Tasneem, Sarosh Khan Jadoon, Maham Tariq, Saddam Hussain, Shahad Saif Khandker, and Sarosh Alvi.
• Registered Medical Practitioner, Azad Jammu & Kashmir Medical College, Muzaffarabad, Azad Jammu and Kashmir, Pakistan.
• Medicine (Baltimore). 2024 Feb 23; 103 (8): e36933e36933.

BackgroundAcute heart failure (AHF) is one of the most common cardiovascular diseases. Early diagnosis and prognosis are essential, as they can eventually lead to a fatal condition. Recently, brain natriuretic peptide (BNP) has been recognized as one of the most popular biomarkers for AHF. Changes in glomerular filtration rate (GFR) are often observed in AHF.MethodsWe searched PubMed, Google Scholar, and ScienceDirect between March and June 2023. Original case control studies written in English that assessed levels oh BNP in AHF were included. Systematic reviews, letters to editor, correspondence, comprehensive reviews, and duplicated studies were excluded. Funnel plots were constructed to assess publication bias.ResultsA total of 9 studies were selected and we obtained the mean difference (MD) of BNP level to be 2.57 (95% CI: 1.35, 3.78), and GFR to be -15.52, (95% CI: -23.35, -7.70) in AHF patients. Sensitivity analyses supported the robustness of the outcome.ConclusionResults indicated that BNP was a promising prognostic biomarker of AHF, whereas GFR was found to be negatively correlated with AHF.Copyright © 2024 the Author(s). Published by Wolters Kluwer Health, Inc.

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