• Annals of surgery · Aug 2024

    Randomized Controlled Trial Multicenter Study

    The Effect of Perioperative Dexamethasone on Postoperative Complications after Pancreaticoduodenectomy: A Multicenter Randomized Controlled Trial.

    • Haoda Chen, Ying Wang, Kuirong Jiang, Zhiwei Xu, Yu Jiang, Zhichong Wu, Xiaojian Lu, Chao Wang, Yuanchi Weng, Weishen Wang, Rui Ding, Shifan Zheng, Yilong Li, Xu Fu, Guodong Shi, Jiancheng Wang, Hao Chen, Chenghong Peng, Xiaxing Deng, Yudong Qiu, Yan Luo, Bei Sun, and Baiyong Shen.
    • Department of General Surgery, Pancreatic Disease Center, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
    • Ann. Surg. 2024 Aug 1; 280 (2): 222228222-228.

    ObjectiveTo evaluate the effect of perioperative dexamethasone on postoperative complications after pancreaticoduodenectomy.BackgroundThe glucocorticoid dexamethasone has been shown to improve postoperative outcomes in surgical patients, but its effects on postoperative complications after pancreaticoduodenectomy are unclear.MethodsThis multicenter, double-blind, randomized controlled trial was conducted in four Chinese high-volume pancreatic centers. Adults undergoing elective pancreaticoduodenectomy were randomized to receive either 0.2 mg/kg dexamethasone or a saline placebo as an intravenous bolus within 5 minutes after anesthesia induction. The primary outcome was the Comprehensive Complication Index (CCI) score within 30 days after the operation, analyzed using the modified intention-to-treat principle.ResultsAmong 428 patients for eligibility, 300 participants were randomized and 265 were included in the modified intention-to-treat analyses. One hundred thirty-four patients received dexamethasone and 131 patients received a placebo. The mean (SD) CCI score was 14.0 (17.5) in the dexamethasone group and 17.9 (20.3) in the placebo group (mean difference: -3.8; 95% CI: -8.4 to 0.7; P = 0.100). The incidence of major complications (Clavien-Dindo grade ≥III; 12.7% vs 16.0%, risk ratio: 0.79; 95% CI: 0.44 to 1.43; P = 0.439) and postoperative pancreatic fistula (25.4% vs 31.3%, risk ratio: 0.81; 95% CI: 0.55 to 1.19; P = 0.286) were not significantly different between the two groups. In the stratum of participants with a main pancreatic duct ≤3 mm (n = 202), the CCI score was significantly lower in the dexamethasone group (mean difference: -6.4; 95% CI: -11.2 to -1.6; P = 0.009).ConclusionsPerioperative dexamethasone did not significantly reduce postoperative complications within 30 days after pancreaticoduodenectomy.Copyright © 2024 Wolters Kluwer Health, Inc. All rights reserved.

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