• Antimicrob. Agents Chemother. · Feb 2013

    KPC presence in Pseudomonas aeruginosa has minimal impact on the in vivo efficacy of carbapenem therapy.

    • Mao Hagihara, Jared L Crandon, Carl M Urban, and David P Nicolau.
    • Center for Anti-Infective Research and Development, Hartford Hospital, Hartford, Connecticut, USA.
    • Antimicrob. Agents Chemother. 2013 Feb 1;57(2):1086-8.

    AbstractWhile reports of Klebsiella pneumoniae carbapenemase (KPC) production among Pseudomonas aeruginosa strains have emerged from a number of countries worldwide, outcome data are lacking. This is the first report evaluating how KPC production in P. aeruginosa impacts the efficacy of carbapenems by using the murine thigh infection model. Our findings suggest that the impact of KPC-2 in vivo is less pronounced than would be anticipated based on the in vitro potency.

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