• Wien. Klin. Wochenschr. · Feb 2024

    [Cell-based influenza vaccines: an effective vaccine option for under 60-year-olds].

    • Barbara C Gärtner, Dietmar Beier, Gunther Gosch, Klaus Wahle, Luise Wendt, Laura-Christin Förster, Kim J Schmidt, and Tino F Schwarz.
    • Institut für Medizinische Mikrobiologie und Hygiene, Universitätsklinikum des Saarlandes, Homburg/Saar, Deutschland.
    • Wien. Klin. Wochenschr. 2024 Feb 1; 136 (Suppl 2): 354235-42.

    AbstractThe population < 60 years of age is also affected by a significant disease burden from seasonal influenza. It carries a high economic burden, mainly driven by influenza-associated productivity losses in the working population. Conventional egg-based influenza vaccines may experience reduced effectiveness due to antigen adaptation in eggs. In contrast, cell-based influenza vaccines are less likely to be affected by antigenic adaptations to the host system and showed better effectiveness in individuals 4-64 years old over several seasons compared to conventional egg-based influenza vaccines under real-world conditions. Preferential use of cell-based influenza vaccines, as opposed to conventional egg-based vaccines, could reduce the burden of influenza-related symptoms on individuals and alleviate the economic impact on the German population < 60 years of age.© 2024. The Author(s).

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