• Vijay Kumar Sharma, Pratibha Kandel, Sujata Baidya, Smrity Rajkarnikar, Apeksha Niraula, Eans Tara Tuladhar, Aseem Bhattarai, Mithileshwer Raut, Raju Kumar Dubey, and Poonam Koirala.
• Department of Clinical Biochemistry, Institute of Medicine, Tribhuvan University Teaching Hospital, Maharajgunj, Kathmandu, Nepal.
• JNMA J Nepal Med Assoc. 2024 Feb 24; 62 (270): 828482-84.

IntroductionPolycystic ovary syndrome is a common hormonal disorder that affects women of reproductive age which is characterized by hyperandrogenism, polycystic ovarian morphology, ovarian dysfunction, and hyperinsulinemia. Increased prevalence of cardiovascular disease and higher cardiovascular morbidity is seen in women with polycystic ovary syndrome. This study aimed to estimate the prevalence of high serum homocysteine levels among women with polycystic ovarian syndrome visiting an infertility clinic of a tertiary care centre.MethodsThis was a descriptive cross-sectional study conducted among women with polycystic ovarian syndrome visiting an infertility clinic at the Department of Obstetrics and Gynaecology of a tertiary care centre from 1 June 2023 to 1 September 2023. The study was conducted after obtaining ethical approval from the Institutional Review Committee. Biochemical analysis of gonadal hormones, serum homocysteine and lipid profile was done. A convenience sampling method was used. The point estimate was calculated at a 95% confidence interval.ResultsAmong 76 women, the prevalence of high serum homocysteine level was found in 54 (71.05%) (60.86-81.25, 95% Confidence Interval). The mean age of patients was 27.46±6.18 years.ConclusionsThe prevalence of high homocysteine levels among women with polycystic ovarian syndrome is higher than other studies done in similar settings.Keywordsbody mass index; homocysteine; polycystic ovary syndrome; prevalence.

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