• Menbeu Sultan, Ayalew Zewdie, Dilanthi Priyadarshani, Ephrem Hassen, Melkamu Tilahun, Tigist Geremew, Abi Beane, Rashan Haniffa, Sean M Berenholtz, William Checkley, Bhakti Hansoti, and Adam D Laytin.
• St. Paul's Hospital Millennium Medical Center, Addis Ababa, Ethiopia.
• J Crit Care. 2024 Jun 1; 81: 154525154525.

PurposeIntensive care units (ICUs) in low- and middle-income countries have high mortality rates, and clinical data are needed to guide quality improvement (QI) efforts. This study utilizes data from a validated ICU registry specially developed for resource-limited settings to identify evidence-based QI priorities for ICUs in Ethiopia.Materials And MethodsA retrospective cohort analysis of data from two tertiary referral hospital ICUs in Addis Ababa, Ethiopia from July 2021-June 2022 was conducted to describe casemix, complications and outcomes and identify features associated with ICU mortality.ResultsAmong 496 patients, ICU mortality was 35.3%. The most common reasons for ICU admission were respiratory failure (24.0%), major head injury (17.5%) and sepsis/septic shock (13.3%). Complications occurred in 41.0% of patients. ICU mortality was higher among patients with respiratory failure (46.2%), sepsis (66.7%) and vasopressor requirements (70.5%), those admitted from the hospital ward (64.7%), and those experiencing major complications in the ICU (62.3%).ConclusionsIn this study, ICU mortality was high, and complications were common and associated with increased mortality. ICU registries are invaluable tools to understand local casemix and clinical outcomes, especially in resource-limited settings. These findings provide a foundation for QI efforts and a baseline to evaluate their impact.Copyright © 2024 The Authors. Published by Elsevier Inc. All rights reserved.

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