• Pramod K Guru, Prasanth Balasubramanian, Manoj Ghimire, J Kyle K Bohman, Troy G Seelhammer, Kianoush B Kashani, and Gregory J Schears.
• Department of Critical Care Medicine, Department of Transplantation, Division of Nephrology & Hypertension, Mayo Clinic, Jacksonville, FL, USA. Electronic address: guru.pramod@mayo.edu.
• J Crit Care. 2024 Jun 1; 81: 154528154528.

PurposeAcute Kidney Injury (AKI) occurs in up to 85% of patients managed by ECMO support. Limited data are available comparing the outcomes among patients who develop AKI before and after ECMO initiation.MethodsA retrospective longitudinal observational study was performed on all adult patients placed on ECMO from January 2000 to December 2015 at our institution. Longitudinal multivariate logistic regressional analysis was performed to identify the variables that are associated with the outcome measures (post-ECMO AKI and in-hospital mortality).ResultsA total of 329 patients were included in our analysis in which AKI occurred in 176 (53%) and 137 (42%) patients before and after ECMO, respectively. In the multivariate analysis, increasing age, pre-existing chronic kidney disease (CKD), increasing bilirubin, decreasing fibrinogen, and use of LVAD had significant association with post-ECMO AKI. In-hospital mortality was seen in 128 out of 176 (73%) patients in the pre-ECMO AKI group and 32 out of 137 (42%) in the post-ECMO AKI group. In the multivariate analysis, age, interstitial lung disease, pre-ECMO AKI, and post-ECMO RRT requirement were independently associated with mortality.ConclusionAKI before ECMO initiation and the need for RRT post-ECMO are independently associated with poor patient survival.Copyright © 2024 Elsevier Inc. All rights reserved.

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