• Barbara Zanini, Federica Benini, Monica Marullo, Anna Simonetto, Angelo Rossi, Paola Cavagnoli, Alessia Bonalumi, Silvia Marconi, Marie Graciella Pigozzi, Gianni Gilioli, Alessandra Valerio, Francesco Donato, Maurizio Castellano, and Chiara Ricci.
• Department of Clinical and Experimental Sciences, University of Brescia, Viale Europa 11, Brescia, Italy.
• Int. J. Clin. Pract. 2024 Jan 1; 2024: 88611268861126.

ResultsOne hundred and fifty five subjects aged 20-59 years underwent (i) liver ultrasound (US), (ii) clinical and anthropometric evaluations, (iii) blood tests, and (iv) assessment of dietary habits. According to US evaluation, 73 of them had severe, moderate, or mild liver steatosis (NAFLD patients) and 82 had no liver steatosis (healthy controls). Fifty-eight NAFLD patients and 73 controls completed the study. Among NAFLD patients, 26 (45%) downgraded steatosis severity, 12 of which achieved complete steatosis regression (21%). Three of the healthy controls developed NAFLD. The NAFLD patients improved their dietary habits and reduced BMI and waist circumference, during the study period, more than healthy controls. Liver steatosis remission/regression was independent of changes in BMI or liver enzymes and was more frequent among patients with mild steatosis at baseline.ConclusionsMediterranean dietary advices, without a personalised meal planning, were efficient in reducing/remitting NAFLD, especially among patients with mild disease, which argues in favour of early identification and lifestyle intervention. This trial is registered with NCT03300661.Copyright © 2024 Barbara Zanini et al.

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