• Simon Corrado Serafini, van MeenenDavid M PDMPDepartment of Intensive Care, Amsterdam UMC, location 'AMC', Amsterdam, the Netherlands; Department of Anesthesiology, Amsterdam UMC, location 'AMC', Amsterdam, the Netherlands., Luigi Pisani, NetoAry SerpaASAustralian and New Zealand Intensive Care Research Centre (ANZIC-RC), School of Public Health and Preventive Medicine, Monash University, Melbourne, Australia; Department of Critical Care, Melbourne Medical School, University of Melbourne, , Lorenzo Ball, Marcelo Gama de Abreu, Anna Geke Algera, Luciano Azevedo, Giacomo Bellani, Arjen M Dondorp, Eddy Fan, John G Laffey, Tai Pham, Edda M Tschernko, Marcus J Schultz, van der WoudeMargaretha C EMCEDepartment of Intensive Care, Amsterdam UMC, location 'AMC', Amsterdam, the Netherlands., ERICC, LUNG SAFE, PRoVENT, and PRoVENT-iMiC-investigators.
• Department of Surgical Sciences and Integrated Diagnostics (DISC), University of Genoa, Genova, Italy; Department of Intensive Care, Amsterdam UMC, location 'AMC', Amsterdam, the Netherlands. Electronic address: simonserafini@gmail.com.
• J Crit Care. 2024 Jun 1; 81: 154531154531.

PurposeWe investigated driving pressure (ΔP) and mechanical power (MP) and associations with clinical outcomes in critically ill patients ventilated for reasons other than ARDS.Materials And MethodsIndividual patient data analysis of a pooled database that included patients from four observational studies of ventilation. ΔP and MP were compared among invasively ventilated non-ARDS patients with sepsis, with pneumonia, and not having sepsis or pneumonia. The primary endpoint was ΔP; secondary endpoints included MP, ICU mortality and length of stay, and duration of ventilation.ResultsThis analysis included 372 (11%) sepsis patients, 944 (28%) pneumonia patients, and 2040 (61%) patients ventilated for any other reason. On day 1, median ΔP was higher in sepsis (14 [11-18] cmH2O) and pneumonia patients (14 [11-18]cmH2O), as compared to patients not having sepsis or pneumonia (13 [10-16] cmH2O) (P < 0.001). Median MP was also higher in sepsis and pneumonia patients. ΔP, as opposed to MP, was associated with ICU mortality in sepsis and pneumonia patients.ConclusionsThe intensity of ventilation differed between patients with sepsis or pneumonia and patients receiving ventilation for any other reason; ΔP was associated with higher mortality in sepsis and pneumonia patients.RegistrationThis post hoc analysis was not registered; the individual studies that were merged into the used database were registered at clinicaltrials.gov: NCT01268410 (ERICC), NCT02010073 (LUNG SAFE), NCT01868321 (PRoVENT), and NCT03188770 (PRoVENT-iMiC).Copyright © 2024 The Authors. Published by Elsevier Inc. All rights reserved.

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