• Atul Dilawri, Justin Muir, Daniel Brodie, Darryl Abrams, Cara Agerstrand, Purnema Madahar, and Amy L Dzierba.
• Department of Pharmacy, NewYork-Presbyterian Hospital, New York, NY, United States of America.
• J Crit Care. 2024 Jun 1; 81: 154534154534.

PurposeThis study aimed to survey critical care clinicians and characterize their perception of antimicrobial dosing strategies in patients receiving extracorporeal membrane oxygenation (ECMO).MethodsInternational, cross-sectional survey distributed to members of the Society of Critical Care Medicine in October 2022.ResultsRespondents were primarily physicians (45%), with 92% practicing in North America. Ninety-seven percent of respondents reported antimicrobial dosing in critically ill patients to be challenging, due to physiological derangements seen in the patient population. Eighty-seven percent reported consideration of physicochemical drug properties when dosing antimicrobials in ECMO-supported patients, with lipophilicity (83%) and degree of protein binding (74%) being the two most common. Respondents' approach to antimicrobial dosing strategies did not significantly differ in critically ill ECMO-supported patients, compared to patients with equal severity of illness not receiving ECMO support.ConclusionApproaches to antimicrobial dosing strategies do not significantly differ among respondents between critically ill patients on ECMO support, compared to patients with equal severity of illness not receiving ECMO support. These findings were unexpected considering the added physiologic complexity of the ECMO circuit to critically ill adult patients and the need for well designed and adequately powered studies to inform empiric dosing guidance for ECMO-supported patients.Copyright © 2024 Elsevier Inc. All rights reserved.

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