• Jialin Meng, Yi Liu, Shi-Yang Guan, Huiya Ma, Xiaoyu Zhang, Song Fan, Huaqing Hu, Meng Zhang, and Chaozhao Liang.
• Department of Urology, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui, China.
• Int. J. Clin. Pract. 2019 Oct 21: e13438e13438.

AimsSeveral studies have reported a potential association between prostate volume (PV) and prostate disease. Here, we classified the risk factors for PV among benign prostatic hyperplasia (BPH) patients.MethodsIn all, 4293 BPH patients with available clinical information were enrolled. Body mass index (BMI) was obtained as weight divided by height squared. PV was calculated as length × width × height (cm) × π/6. Mann-Whitney U tests were used to determine the differences between PV subgroups. Univariate and multiple linear regression tests were performed to uncover the connection between clinical features and PV. The differences in the age, BMI, height and fasting blood glucose (FBG) of the subgroups were evaluated by Kruskal-Wallis tests and adjusted with Bonferroni post hoc correction. A nomogram was created to directly illustrate the mutual interaction of amalgamator parameters.ResultsPV did not influence the incidence of kidney stones (P = .815), whereas prostate calculi were positively associated with an enlarged prostate (>30 mL) (P < .001). Age (adjusted R = 0.363, P < .001), height (adjusted R = 0.088, P < .001), BMI (adjusted R = 0.039, P = .013) and FBG (adjusted R = -0.034, P = .027) were the independent risk/protective factors related to enlarged PV among BPH patients. The nomogram illustrated the predictive risk of an enlarged prostate (>30 mL) in men. The area under the ROC curve value was 0.659 in the training cohort and 0.677 in an internal validation cohort.ConclusionsAge, height and BMI were positive independent risk factors of enlarged PV in BPH patients, and FBG had a protective role.© 2019 John Wiley & Sons Ltd.

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