• Emilie Gregers, Louise Linde, KunkelJoakim BoJBDepartment of Cardiology, Copenhagen University Hospital Rigshospitalet, Denmark; Department of Clinical Medicine, Copenhagen University, Denmark., Sebastian Wiberg, Peter Hasse Møller-Sørensen, Morten Smerup, Britt Borregaard, Henrik Schmidt, Jens Flensted Lassen, Jacob Eifer Møller, Christian Hassager, Helle Søholm, and Jesper Kjærgaard.
• Department of Cardiology, Copenhagen University Hospital Rigshospitalet, Denmark; Department of Cardiothoracic Surgery, Copenhagen University Hospital Rigshospitalet, Denmark; Department of Clinical Medicine, Copenhagen University, Denmark. Electronic address: ehan0049@regionh.dk.
• Resuscitation. 2024 Apr 1; 197: 110151110151.

BackgroundExtracorporeal cardiopulmonary resuscitation (ECPR) for selected refractory out-of-hospital cardiac arrest (OHCA) is increasingly used. Detailed knowledge of health-related quality of life (HRQoL) and long-term cognitive function is limited. HRQoL and cognitive function were assessed in ECPR-survivors and OHCA-survivors with prehospital return of spontaneous circulation after standard advanced cardiac life support (sACLS).MethodsFifteen ECPR-survivors and 22 age-matched sACLS-survivors agreed to participate in this follow-up study. Participants were examined with echocardiography, 6-minute walk test, and neuropsychological testing, and answered HRQoL (EQ-5D-5L and Short Form 36 (SF-36)), and mental health questionnaires.ResultsMost patients were male (73 % and 82 %) and median age at follow-up was similar between groups (55 years and 60 years). Low flow time was significantly longer for ECPR-survivors (86 min vs. 15 min) and lactate levels were significantly higher (14.1 mmol/l vs. 3.9 mmol/l). No between-group difference was found in physical function nor in cognitive function with scores corresponding to the 23rd worst percentile of the general population. SACLS-survivors had HRQoL on level with the Danish general population while ECPR-survivors scored lower in both EQ-5D-5L (index score 0.73 vs. 0.86, p = 0.03, visual analog scale: 70 vs. 84, p = 0.04) and in multiple SF-36 health domains (role physical, bodily pain, general health, and mental health).ConclusionsDespite substantially longer low flow times with thrice as high lactate levels, ECPR-survivors were similar in cognitive and physical function compared to sACLS-survivors. Nonetheless, ECPR-survivors reported lower HRQoL overall and related to mental health, pain management, and the perception of limitations in physical role.Copyright © 2024 The Author(s). Published by Elsevier B.V. All rights reserved.

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