• Valmir Jose de Lima, Claudia Roberta de Andrade, Gustavo Enrico Ruschi, and Nelson Sass.
• Obstetrics Department, Universidade Federal de São Paulo, Brazil. valmirlima.es@uol.com.br
• Sao Paulo Med J. 2011 Mar 1; 129 (2): 737673-6.

Context And ObjectivePre-eclampsia is a disorder that occurs only during pregnancy. Postpartum changes relating to lipid metabolism may contribute towards the endothelial lesions observed in preeclampsia. Thus, the aim of the present study was to evaluate the lipid profile among patients who present preeclampsia and correlate these parameters with 24-hour proteinuria.Design And SettingCross-sectional analytical study including 77 pregnant patients seen at Hospital Dório Silva.MethodsThis study involved 42 women with preeclampsia and 35 healthy pregnant women in the third trimester of pregnancy as controls. Blood samples were obtained from all the patients, and the serum levels of triglycerides, total cholesterol, low-density lipoproteins (LDL), high-density lipoproteins (HDL) and very low density lipoproteins (VLDL) were determined. Cases and controls were matched for maternal age, gestational week and body mass index.ResultsThe VLDL and triglyceride values from the women with preeclampsia were significantly higher than those of the healthy women. There was a positive correlation between increased proteinuria and higher VLDL and triglyceride levels in patients with preeclampsia.ConclusionAmong the patients with preeclampsia, higher VLDL and triglyceride levels were positively correlated with proteinuria. These observations indicate that the pregnant women who presented elevated lipid levels were more susceptible to cardiovascular disorders and, consequently, pre-eclampsia.

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