• Farjoud KouhanjaniMohsenM0000-0001-5877-7865Clinical Microbiology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran., Seyed Ali Hosseini, Seyedeh Maryam Mousavi, Zahra Noroozi, Paniz Sadeghi, Armita Jokar-Derisi, Mohammad Saleh Jamshidi Mouselou, Meysam Ahmadi, and Armin Attar.
• Clinical Microbiology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
• Int. J. Clin. Pract. 2024 Jan 1; 2024: 72592007259200.

IntroductionTakotsubo cardiomyopathy (TCM) features transient left ventricular apical dysfunction or ballooning. The underlying mechanism remains elusive; however, evidence suggests the role of different physical and psychological stressors. We systematically reviewed patients presenting with TCM and autoimmunity to explore the link between the two conditions.MethodsWe applied the Preferred Reporting Items for Systematic reviews and Meta-Analyses extension for Scoping Reviews (PRISMA-ScR) to report this review. Using keywords related to autoimmune/immune-mediated diseases and TCM, we searched PubMed, Scopus, and WOS in March 2022. The final results were added to a data extraction sheet. Data were analyzed by SPSS version 26.0.ResultsOur search yielded 121 studies, including 155 patients. Females were considerably predominant. Most patients had a history of autoimmune disease, and almost a third had a history of cardiovascular disease. Dyspnea and chest pain were the most common chief complaints. More than 70% of patients had experienced physical stress. Myasthenia gravis, systemic lupus erythematosus, and multiple sclerosis were the most frequently reported autoimmune diseases.ConclusionThere were similarities in age and sex compared to classic TCM. TCM should be considered as a differential diagnosis for ACS, especially in patients with a positive background of autoimmunity. A precise reporting system is required for further studies.Copyright © 2024 Mohsen Farjoud Kouhanjani et al.

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