Toxicities, intensive care management, and outcome of chimeric

Crit Care · Mar 2024

Review

Toxicities, intensive care management, and outcome of chimeric antigen receptor T cells in adults: an update.

Chimeric antigen receptor T cells are a promising new immunotherapy for haematological malignancies. Six CAR-T cells products are currently available for adult patients with refractory or relapsed high-grade B cell malignancies, but they are associated with severe life-threatening toxicities and side effects that may require admission to ICU. ⋯ The aim of this short pragmatic review is to synthesize for intensivists the knowledge on CAR-T cell therapy with emphasis on CAR-T cell-induced toxicities and ICU management of complications according to international recommendations, outcomes and future issues.

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- Mathieu Bellal, Jolan Malherbe, Gandhi Damaj, and Damien Du Cheyron.
- Department of Medical Intensive Care, Caen University Hospital, Avenue de la côte de nacre, 14000, Caen, France. mathieu.bellal@gmail.com.
- Crit Care. 2024 Mar 5; 28 (1): 6969.
BackgroundChimeric antigen receptor T cells are a promising new immunotherapy for haematological malignancies. Six CAR-T cells products are currently available for adult patients with refractory or relapsed high-grade B cell malignancies, but they are associated with severe life-threatening toxicities and side effects that may require admission to ICU.ObjectiveThe aim of this short pragmatic review is to synthesize for intensivists the knowledge on CAR-T cell therapy with emphasis on CAR-T cell-induced toxicities and ICU management of complications according to international recommendations, outcomes and future issues.© 2024. The Author(s).

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Toxicities, intensive care management, and outcome of chimeric antigen receptor T cells in adults: an update.

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