• Internal medicine · Jan 2024

    Case Reports

    Anti-contactin 1 Antibody-associated Membranous Nephropathy in Chronic Inflammatory Demyelinating Polyneuropathy with Several Autoantibodies.

    • Ryutaro Shida, Takamasa Iwakura, Naro Ohashi, Chiemi Ema, Taro Aoki, Takeshi Tashiro, Sayaka Ishigaki, Shinsuke Isobe, Tomoyuki Fujikura, Akihiko Kato, Tomohiko Nakamura, Yoshihide Fujigaki, Akira Shimizu, and Hideo Yasuda.
    • First Department of Medicine, Division of Nephrology, Hamamatsu University School of Medicine, Japan.
    • Intern. Med. 2024 Jan 1; 63 (5): 699705699-705.

    AbstractA 50-year-old man diagnosed with anti-contactin 1 (CNTN1) antibody-associated chronic inflammatory demyelinating polyneuropathy (CIDP) was referred to our department for the evaluation of proteinuria. A kidney biopsy revealed membranous nephropathy (MN). Immunohistochemistry for CNTN1 revealed positive granular staining along the glomerular basement membrane, confirming anti-CNTN1 antibody-associated MN. Immunofluorescence showed a full-house pattern, and several autoantibodies, such as anti-nuclear antibody, anti-double-strand DNA antibody, and anti-cardiolipin antibody, were detected in the patient's serum. Although limited autoantibodies have been investigated in some of the reported cases, a variety of autoantibodies might be produced in anti-CNTN1 antibody-associated CIDP, accompanied by MN.

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