• Internal medicine · Nov 2024

    Case Reports

    A Case of Successful Immunosuppressive Therapy for Interstitial Lung Disease Associated with Sjögren's Syndrome With Double-positive Anti-SS-A and Anti-centromere Antibodies.

    • Koji Suzuki, Mitsuhiro Akiyama, Yasushi Kondo, Shuntaro Saito, Jun Kikuchi, Hironari Hanaoka, and Yuko Kaneko.
    • Division of Rheumatology, Department of Internal Medicine, Keio University School of Medicine, Japan.
    • Intern. Med. 2024 Nov 1; 63 (21): 298729902987-2990.

    AbstractSjögren's syndrome (SS) can present with extraglandular organs, such as interstitial lung disease (ILD). Anti-SS-A antibody is frequently found in SS cases, whereas anti-centromere antibody (ACA) is detected in some SS cases. Notably, the anti-SS-A and ACA double-positive cases exhibited distinct features with a higher prevalence of ILD. However, there have so far been no reports on the treatment of ILD in anti-SS-A and ACA double-positive cases. We herein present a case of ILD with anti-SS-A and ACA double-positive SS that was successfully treated with immunosuppressive therapy. Our case suggests the potential efficacy of immunosuppressive therapy for this poorly understood condition.

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