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- Ioana Medrea, Stewart J Tepper, Donliang Wang, Paul G Mathew, and Mark Burish.
- SUNY Upstate Medical University, Syracuse, New York, USA. medreai@upstate.edu.
- J Headache Pain. 2024 Mar 7; 25 (1): 3232.
BackgroundNew guidelines for cluster headache clinical trials were recently published. We welcome these new guidelines and raise additional considerations in trial methodologies.Main BodyWe present non-inferiority trials to overcome ethical issues with placebo use, and additionally discuss issues with trial recruitment.ConclusionsWe highlight some possible issues and solutions to be considered with the recently published cluster headache trial guidelines.© 2024. The Author(s).
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