• Peter Theiss, Ahmed Essam Ali, Laura Stone McGuire, Giuseppe Lanzino, Sherief Ghozy, Waleed Brinjikji, NaamaniKareem ElKE3Department of Neurosurgery, Thomas Jefferson University Hospital, Philadelphia, Pennsylvania., Abdelaziz Amllay, Stavropoula I Tjoumakaris, Pascal Jabbour, Mohamed M Salem, Jan-Karl Burkhardt, Brian T Jankowitz, Adib Abla, Daniel A Tonetti, Peter T Kan, Ariadna Robledo, and Ali Alaraj.
• 1Department of Neurosurgery, University of Illinois at Chicago, Illinois.
• J. Neurosurg. 2024 Aug 1; 141 (2): 310315310-315.

ObjectiveTreatment of intracranial aneurysms by flow diversion is safe and effective and is increasingly popular. However, the correct treatment paradigm for aneurysms incompletely treated by initial placement of a flow diverter has not been established, nor have the subsequent natural history and occlusion rates of such aneurysms. The authors sought to outline the natural history of such aneurysms, which to date have been considered partially treated.MethodsThe authors retrospectively reviewed consecutive cases from 6 high-volume neurointerventional services, including all cases in which the first follow-up imaging after placement of a flow diverter showed incomplete occlusion of the aneurysm, and for which subsequent clinical and/or radiological follow-up was available. All included patients were treated with the Pipeline Flex embolization device or the Pipeline Flex embolization device with Shield Technology. Subsequent radiographic and clinical outcome data were collected and analyzed using the Kaplan-Meier survival function.ResultsA total of 263 patients with persistently patent aneurysms on first follow-up imaging after flow diversion were identified. Of these, 204 had clinical follow-up and 152 had additional imaging follow-up. Of this final cohort, 148 aneurysms were unruptured, and 4 were ruptured. The average aneurysm size by maximum dimension was 10.8 mm. The average recorded follow-up was 27.8 months in the cohort, with some patients followed for as long as 9 years from treatment. Over the course of 403 person-years of follow-up, no delayed aneurysm ruptures were recorded. Both with and without retreatment, aneurysms showed a trend toward progressive occlusion over time. Complications related to device placement were low.ConclusionsAneurysms that have been incompletely treated by flow diversion have a benign natural history with progression toward occlusion over time, with or without retreatment.

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