• Wenchen Luo, Danfeng Jin, Jian Huang, Jinlin Zhang, Yongfeng Xu, Jiahui Gu, Caihong Sun, Jian Yu, Peiyao Xu, Luping Liu, Zhenyu Zhang, Chenyue Guo, Hongjin Liu, Changhong Miao, and Jing Zhong.
• Department of Anesthesiology, Zhongshan Hospital Fudan University, Shanghai, China.
• Ann. Surg. 2024 Apr 1; 279 (4): 588597588-597.

ObjectiveTo compare the effect of low and standard pneumoperitoneal pressure (PP) on the occurrence of gas embolism during laparoscopic liver resection (LLR).BackgroundLLR has an increased risk of gas embolism. Although animal studies have shown that low PP reduces the occurrence of gas embolism, clinical evidence is lacking.MethodsThis parallel, dual-arm, double-blind, randomized controlled trial included 141 patients undergoing elective LLR. Patients were randomized into standard ("S," 15 mm Hg; n = 70) or low ("L," 10 mm Hg; n = 71) PP groups. Severe gas embolism (≥ grade 3, based on the Schmandra microbubble method) was detected using transesophageal echocardiography and recorded as the primary outcome. Intraoperative vital signs and postoperative recovery profiles were also evaluated.ResultsFewer severe gas embolism cases (n = 29, 40.8% vs n = 47, 67.1%, P = 0.003), fewer abrupt decreases in end-tidal carbon dioxide partial pressure, shorter severe gas embolism duration, less peripheral oxygen saturation reduction, and fewer increases in heart rate and lactate during gas embolization episodes was found in group L than in group S. Moreover, a higher arterial partial pressure of oxygen and peripheral oxygen saturation were observed, and fewer fluids and vasoactive drugs were administered in group L than in group S. In both groups, the distensibility index of the inferior vena cava negatively correlated with central venous pressure throughout LLR, and a comparable quality of recovery was observed.ConclusionsLow PP reduced the incidence and duration of severe gas embolism and achieved steadier hemodynamics and vital signs during LLR. Therefore, a low PP strategy can be considered a valuable choice for the future LLR.Copyright © 2023 The Author(s). Published by Wolters Kluwer Health, Inc.

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