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- Yann-Erick Claessens, Jean-Daniel Chiche, Jean-Paul Mira, and Alain Cariou.
- Service de Réanimation Polyvalente, Hôpital Cochin and Institut Cochin, Paris, France. yann-erick.claessens@cch.ap-hop-paris.fr
- Crit Care. 2003 Jun 1; 7 (3): 226232226-32.
AbstractNucleoside reverse transcriptase inhibitors (NRTIs) are effective antiretroviral therapy for the treatment of HIV-infected patients. NRTIs can induce mitochondrial impairment that leads to a number of adverse events, including symptomatic lactic acidosis. In the present review, we describe the underlying mechanism of NRTI-induced toxicity and the main clinical features of this infrequent, but severe, emerging complication. We also summarise experimental data and clinical observations that support the use of L-carnitine supplementation to reverse NRTI-induced mitochondrial impairment.
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