• Annals of medicine · Dec 2024

    Review

    Research progress on the mechanism of common inflammatory pathways in the pathogenesis and development of lymphoma.

    • Aorong Shi, Fen Yun, Lin Shi, Xia Liu, and Yongfeng Jia.
    • Department of Pathology, Basic Medical Sciences College, Inner Mongolia Medical University, Hohhot, China.
    • Ann. Med. 2024 Dec 1; 56 (1): 23291302329130.

    AbstractIn recent years, the incidence and mortality rates of lymphoma have gradually increased worldwide. Tumorigenesis and drug resistance are closely related to intracellular inflammatory pathways in lymphoma. Therefore, understanding the biological role of inflammatory pathways and their abnormal activation in relation to the development of lymphoma and their selective modulation may open new avenues for targeted therapy of lymphoma. The biological functions of inflammatory pathways are extensive, and they are central hubs for regulating inflammatory responses, immune responses, and the tumour immune microenvironment. However, limited studies have investigated the role of inflammatory pathways in lymphoma development. This review summarizes the relationship between abnormal activation of common inflammatory pathways and lymphoma development to identify precise and efficient targeted therapeutic options for patients with advanced, drug-resistant lymphoma.

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