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- Shingo Yokoyama, Kota Kakeshita, Teruhiko Imamura, Tomoko Shima, Hayato Fujioka, Hidenori Yamazaki, Tsutomu Koike, and Koichiro Kinugawa.
- The Second Department of Internal Medicine, University of Toyama, Japan.
- Intern. Med. 2024 Oct 15; 63 (20): 283928452839-2845.
AbstractPegylated liposomal doxorubicin (PLD) has emerged as a recent innovation within the realm of antineoplastic agents, distinguished by its incorporation of doxorubicin within the liposomal bilayer. Given the low risk of cardiotoxicity, the clinical use of PLD has been expanding. We encountered a patient who underwent extended PLD therapy for recurrent malignancy and subsequently developed PLD-associated thrombotic microangiopathy, which was diagnosed by a detailed pathophysiological assessment. This case underscores the importance of considering thrombotic microangiopathy as a potential differential diagnosis in patients presenting with unexplained hypertension and renal impairment during prolonged PLD monotherapy.
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