• Esra Rizaogullari Guzel, Nihan Cansel Sarkaya, Ayşegul Ugur Kurtoglu, Volkan Karakus, and Erdal Kurtoglu.
• Antalya Training and Research Hospital, Internal Medicine Clinic, Antalya Eğitim ve Araştırma Hastanesi, Varlık Mh. Kazım Karabekir Cd. 07100, Antalya, Turkey. esrarizaogullari@gmail.com.
• Ir J Med Sci. 2024 Aug 1; 193 (4): 191119161911-1916.

ObjectivesThis study investigates the roles of HIF-2α, hepcidin, and ghrelin in iron deficiency anemia (IDA), the most widespread nutritional disorder globally.Material And MethodsFifty IDA patients (18-50 years, BMI 19-25) and 40 healthy volunteers were studied. Hemoglobin, ferritin, hepcidin, HIF-2α, and ghrelin levels were analyzed.ResultsIDA patients showed lower hemoglobin, ferritin, hepcidin, and ghrelin levels than the control group, but HIF-2α levels were similar. Positive correlations were observed in both groups between hepcidin and HIF-2α (p < 0.001), hepcidin and ghrelin (p < 0.001), and HIF-2α and ghrelin (p < 0.001). Hemoglobin was correlated positively with HIF-2α, and ferritin was correlated positively with HIF-2α in the patient group.ConclusionThe study suggests that the low hepcidin levels in IDA patients enhance iron absorption. The lack of significant HIF-2α level differences may be due to the absence of chronic hypoxia in current hemoglobin levels of IDA patients. Moreover, the low ghrelin levels in patients and the correlations between ghrelin, hepcidin, and HIF-2α in both groups indicate their involvement in iron metabolism.© 2024. The Author(s), under exclusive licence to Royal Academy of Medicine in Ireland.

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