• World Neurosurg · May 2024

    Radiosurgical decompression of trigeminal nerve and its correlation with functional outcome in tumor related trigeminal neuralgia.

    • Sushanta Kumar Sahoo, Joginder Singh, Anurodh Kumar, Het Upadhyaya, Manoj Kumar Tewari, Renu Madan, Parsee Tomar, and Ranjit Singh.
    • Department of Neurosurgery, Post Graduate Institute of Medical Education and Research, Chandigarh, India. Electronic address: drsushantsahoo@gmail.com.
    • World Neurosurg. 2024 May 1; 185: e1057e1063e1057-e1063.

    BackgroundTarget selection during Gamma Knife radiosurgery (GKRS) in cases of tumor-related trigeminal neuralgia is always debatable. We analyzed the correlation of regression of tumor size and degree of release of the nerve with long-term pain control.MethodsBetween March 2012 and March 2023, 50 cases of tumor-related trigeminal neuralgia were treated with GKRS (tumor was targeted). Radiological findings after GKRS were categorized into 3 types: 1) tumor volume remained same or decreased, additional segment of nerve not seen; 2) tumor volume decreased, additional segment of trigeminal nerve seen, but tumor still adherent to the nerve; 3) tumor volume decreased, adjacent nerve seen completely separated from tumor. Pain score before and after GKRS (Barrow Neurological Institute I-III: good; Barrow Neurological Institute IV and V: poor) was correlated with these subgroups.ResultsAt median follow-up of 46.5 months, 18 cases showed type 1 radiological response, 23 showed type 2 response, and 9 showed type 3 response. Good pain control was achieved in 10 (55.5%) patients with type 1, 15 (65.21%) with type 2, and 7 (77.8%) with type 3 responses. The outcome differences among these 3 groups were not statistically significant (P = 0.519). Five patients with type 3 radiological response were off medication, which was statistically better than type 1 and type 2 radiological responses, with 3 patients (P = 0.012) and 2 patients (P = 0.002), respectively, still receiving medication.ConclusionsTumor volume reduction after GKRS may be associated with good pain control in tumor-related trigeminal neuralgia. Further, this allows visualization of additional segment of nerve that can be targeted in a second session for treating recurrent or failed cases.Copyright © 2024 Elsevier Inc. All rights reserved.

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