Genetically Engineered Microorganisms and Their Impact on

Int. J. Clin. Pract. · Jan 2024

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Genetically Engineered Microorganisms and Their Impact on Human Health.

The emergence of antibiotic-resistant strains, the decreased effectiveness of conventional therapies, and the side effects have led researchers to seek a safer, more cost-effective, patient-friendly, and effective method that does not develop antibiotic resistance. With progress in synthetic biology and genetic engineering, genetically engineered microorganisms effective in treatment, prophylaxis, drug delivery, and diagnosis have been developed. The present study reviews the types of genetically engineered bacteria and phages, their impacts on diseases, cancer, and metabolic and inflammatory disorders, the biosynthesis of these modified strains, the route of administration, and their effects on the environment. We conclude that genetically engineered microorganisms can be considered promising candidates for adjunctive treatment of diseases and cancers.

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- Mahdizade AriMarzieM0000-0002-6285-5886Department of Microbiology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran.Microbial Biotechnology Research Centre, Iran University of Medical Sciences, Tehran, Iran., Leila Dadgar, Zahra Elahi, Roya Ghanavati, and Behrouz Taheri.
- Department of Microbiology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran.
- Int. J. Clin. Pract. 2024 Jan 1; 2024: 66382696638269.
AbstractThe emergence of antibiotic-resistant strains, the decreased effectiveness of conventional therapies, and the side effects have led researchers to seek a safer, more cost-effective, patient-friendly, and effective method that does not develop antibiotic resistance. With progress in synthetic biology and genetic engineering, genetically engineered microorganisms effective in treatment, prophylaxis, drug delivery, and diagnosis have been developed. The present study reviews the types of genetically engineered bacteria and phages, their impacts on diseases, cancer, and metabolic and inflammatory disorders, the biosynthesis of these modified strains, the route of administration, and their effects on the environment. We conclude that genetically engineered microorganisms can be considered promising candidates for adjunctive treatment of diseases and cancers.Copyright © 2024 Marzie Mahdizade Ari et al.

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