• Indian J Med Res · Jan 2013

    Modulation of the norfloxacin resistance in Staphylococcus aureus by Cordia verbenaceae DC.

    • Edinardo F F Matias, Karla K A Santos, Vivyanne S Falcão-Silva, Jose P Siqueira-Junior, Jose G M Costa, and CoutinhoHenrique D MHD.
    • Laboratório de Microbiologia e Biologia Molecular, Universidade Regional do Cariri, Crato, Ceara, Brazil.
    • Indian J Med Res. 2013 Jan 1; 137 (1): 178182178-82.

    Background & ObjectivesSeveral chemical compounds isolated from natural sources have antibacterial activity and some enhance the antibacterial activity of antibiotics reversing the natural resistance of bacteria to certain antibiotics. In this study, the hexane and methanol extract of Cordia verbenaceae were assessed for antibacterial activity alone and combinated with norfloxacin against the Staphylococcus aureus strain SA1199B.MethodsThe minimum inhibitory concentration (MIC) of extracts was assayed using microdilution assay and the modulatory activity was evaluated using plate diffusion assay.ResultsThe MIC observed varied between 256 to >1024 μg/ml. However, the antibiotic activity of norfloxacin was enhanced in the presence of subinhibitory concentrations of hexane extract of C. verbenaceae (HECV). INTERPRETATIONS & CONCLUSIONS: Our results indicate that Cordia verbenaceae DC. can be a source of plant derived products with antibiotic modifying activity.

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