• Curr Opin Anaesthesiol · Aug 2010

    Review

    Sugammadex: a selective relaxant-binding agent providing rapid reversal.

    • Christopher Rex, Urs A Bergner, and Friedrich K Pühringer.
    • Department for Anaesthesia and Intensive Care Medicine, Klinikum am Steinenberg, Academic Hospital of the University of Tübingen, Reutlingen, Germany.
    • Curr Opin Anaesthesiol. 2010 Aug 1;23(4):461-5.

    Purpose Of ReviewSugammadex is a new reversal agent with a unique mechanism of action in anaesthesia. Because of its rapid onset of action and its efficacy in determining neuromuscular blockade at any time, it opens up new perspectives in anaesthesia.Recent FindingsDuring the last few years, a lot of phase II and III studies have been published, investigating various groups of patients and clinical situations. Sugammadex has been shown to be a well tolerated drug, which appears to meet every challenge it is presented with in daily clinical practice.SummarySugammadex binds amino-steroidal muscle relaxants by encapsulation. It enables rapid reversal of neuromuscular blockade at any time point and at any depth of block. Its effects are predictable and very reliable, in contrast to cholinesterase inhibitors. This opens up new perspectives in anaesthesia. Even an emergency reversal of high-dose rocuronium-induced neuromuscular blockade is possible with sugammadex and times to full recovery (TOF 0.9) are faster than after spontaneous recovery from suxamethonium.

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