• Paul G Shekelle, Sally C Morton, Lara K Jungvig, Jay Udani, Myles Spar, Wenli Tu, J SuttorpMarikaM, Ian Coulter, Sydne J Newberry, and Mary Hardy.
• Southern California Evidence-Based Practice Center, Rand Corporation, Santa Monica, California, USA. shekekke@rand.org
• J Gen Intern Med. 2004 Apr 1; 19 (4): 380389380-9.

ObjectiveTo evaluate and synthesize the evidence on the effect of supplements of vitamin E on the prevention and treatment of cardiovascular disease.DesignSystematic review of placebo-controlled randomized controlled trials; meta-analysis where justified.Measurements And Main ResultsEighty-four eligible trials were identified. For the outcomes of all-cause mortality, cardiovascular mortality, fatal or nonfatal myocardial infarction, and blood lipids, neither supplements of vitamin E alone nor vitamin E given with other agents yielded a statistically significant beneficial or adverse pooled relative risk (for example, pooled relative risk of vitamin E alone = 0.96 [95% confidence interval (CI), 0.84 to 1.10]; 0.97 [95% CI, 0.80 to 1.90]; and 0.72 [95% CI, 0.51 to 1.02] for all-cause mortality, cardiovascular mortality, and nonfatal myocardial infarction, respectively.ConclusionsThere is good evidence that vitamin E supplementation does not beneficially or adversely affect cardiovascular outcomes.

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