• Masamichi Sato, Yoko Shibata, Shuichi Abe, Sumito Inoue, Akira Igarashi, Keiko Yamauchi, Yasuko Aida, Hiroyuki Kishi, Keiko Nunomiya, Hiroshi Nakano, Kento Sato, Tetsu Watanabe, Tsuneo Konta, Yoshiyuki Ueno, Takeo Kato, Takamasa Kayama, and Isao Kubota.
• Department of Cardiology, Pulmonology, and Nephrology, Yamagata University School of Medicine, Yamagata, Japan.
• Int J Med Sci. 2013 Jan 1; 10 (1): 171-7.

BackgroundMetabolic syndrome (Mets) is reportedly associated with chronic obstructive pulmonary disease (COPD). However, the relationship between abdominal circumference (AC) and decline in FEV(1) has not been elucidated. We aimed to investigate this relationship among male current smokers.MethodsSpirometry was performed on subjects (n = 3,257) ≥ 40 years of age, who participated in a community-based annual health check in Takahata, Japan, from 2004 through 2006 (visit 1). Spirometry was re-evaluated, and AC was assessed in 147 of the male current smokers in 2009 (visit 2). The diagnosis of Mets was based on the criteria used in the Hisayama Study.ResultsNo significant relationships were observed between AC and spirometric parameters such as % predicted forced vital capacity (FVC), % predicted forced expiratory volume in 1 s (FEV(1)) and FEV(1)/FVC. However, decline in FEV(1) was significantly correlated with AC. Multivariate logistic regression analysis showed that AC was a significant discriminating factor for decline in FEV(1), independently of age, Brinkman index and change in body mass index from visit 1 to visit 2. At visit 2, there was a greater prevalence of decline in FEV(1) among subjects with Mets (n=17) than among those without Mets. Although there were no differences in % predicted FVC, % predicted FEV(1) or FEV(1)/FVC between subjects with or without Mets, the rate of decline in FEV(1) was significantly greater in subjects with Mets than in those without.ConclusionsThis retrospective analysis suggested that measuring AC may be useful for discriminating male smokers who show a decline in FEV(1).

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