• Orlane Brohan, Alexis Chenouard, Aurélie Gaultier, Joseph E Tonna, Peter Rycus, Stefano Pezzato, Andrea Moscatelli, Jean-Michel Liet, Pierre Bourgoin, RozéJean-ChristopheJCPediatric Intensive Care Unit, University Hospital of Nantes, Nantes, France.Clinical Investigation Center (CIC) 1413, INSERM, Public Health, Clinic of the Data, University Hospital of Nantes, Nantes, France., Pierre-Louis Léger, Jérôme Rambaud, and Nicolas Joram.
• Pediatric Intensive Care Unit, University Hospital of Nantes, Nantes, France.
• Pediatr Crit Care Me. 2024 Jul 1; 25 (7): 591598591-598.

ObjectivesExtracorporeal life support can lead to rapid reversal of hypoxemia but the benefits and harms of different oxygenation targets in severely ill patients are unclear. Our primary objective was to investigate the association between the Pa o2 after extracorporeal membrane oxygenation (ECMO) initiation and mortality in neonates treated for respiratory failure.DesignRetrospective analysis of the Extracorporeal Life Support Organization (ELSO) Registry data, 2015-2020.PatientsNewborns supported by ECMO for respiratory indication were included.InterventionsNone.Measurements And Main ResultsPa o2 24 hours after ECMO initiation (H24 Pa o2 ) was reported. The primary outcome was 28-day mortality. We identified 3533 newborns (median age 1 d [interquartile range (IQR), 1-3]; median weight 3.2 kg [IQR, 2.8-3.6]) from 198 ELSO centers, who were placed on ECMO. By 28 days of life, 731 (20.7%) had died. The median H24 Pa o2 was 85 mm Hg (IQR, 60-142). We found that both hypoxia (Pa o2 < 60 mm Hg) and moderate hyperoxia (Pa o2 201-300 mm Hg) were associated with greater adjusted odds ratio (aOR [95% CI]) of 28-day mortality, respectively: aOR 1.44 (95% CI, 1.08-1.93), p = 0.016, and aOR 1.49 (95% CI, 1.01-2.19), p value equals to 0.045.ConclusionsEarly hypoxia or moderate hyperoxia after ECMO initiation are each associated with greater odds of 28-day mortality among neonates requiring ECMO for respiratory failure.Copyright © 2024 by the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies.

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