• Leighton Chan, Mark Hallett, Chris K Zalewski, Carmen C Brewer, Cris Zampieri, Michael Hoa, Sara M Lippa, Edmond Fitzgibbon, Louis M French, Anita D Moses, André J van der Merwe, Carlo Pierpaoli, L Christine Turtzo, Simge Yonter, Pashtun Shahim, NIH AHI Intramural Research Program Team, Brian Moore, Lauren Stamps, Spencer Flynn, Julia Fontana, Swathi Tata, Jessica Lo, Mirella A Fernandez, Annie-Lori Joseph, Jesse Matsubara, Julie Goldberg, Thuy-Tien D Nguyen, Noa Sasson, Justine Lely, Bryan Smith, Kelly A King, Jennifer Chisholm, Julie Christensen, M Teresa Magone, Chantal Cousineau-Krieger, Rakibul Hafiz, Amritha Nayak, Okan Irfanoglu, Sanaz Attaripour, Chen Lai, and Wendy B Smith.
• Rehabilitation Medicine Department, Clinical Center, National Institutes of Health, Bethesda, Maryland.
• JAMA. 2024 Apr 2; 331 (13): 110911211109-1121.

ImportanceSince 2015, US government and related personnel have reported dizziness, pain, visual problems, and cognitive dysfunction after experiencing intrusive sounds and head pressure. The US government has labeled these anomalous health incidents (AHIs).ObjectiveTo assess whether participants with AHIs differ significantly from US government control participants with respect to clinical, research, and biomarker assessments.Design, Setting, And ParticipantsExploratory study conducted between June 2018 and July 2022 at the National Institutes of Health Clinical Center, involving 86 US government staff and family members with AHIs from Cuba, Austria, China, and other locations as well as 30 US government control participants.ExposuresAHIs.Main Outcomes And MeasuresParticipants were assessed with extensive clinical, auditory, vestibular, balance, visual, neuropsychological, and blood biomarkers (glial fibrillary acidic protein and neurofilament light) testing. The patients were analyzed based on the risk characteristics of the AHI identifying concerning cases as well as geographic location.ResultsEighty-six participants with AHIs (42 women and 44 men; mean [SD] age, 42.1 [9.1] years) and 30 vocationally matched government control participants (11 women and 19 men; mean [SD] age, 43.8 [10.1] years) were included in the analyses. Participants with AHIs were evaluated a median of 76 days (IQR, 30-537) from the most recent incident. In general, there were no significant differences between participants with AHIs and control participants in most tests of auditory, vestibular, cognitive, or visual function as well as levels of the blood biomarkers. Participants with AHIs had significantly increased fatigue, depression, posttraumatic stress, imbalance, and neurobehavioral symptoms compared with the control participants. There were no differences in these findings based on the risk characteristics of the incident or geographic location of the AHIs. Twenty-four patients (28%) with AHI presented with functional neurological disorders.Conclusions And RelevanceIn this exploratory study, there were no significant differences between individuals reporting AHIs and matched control participants with respect to most clinical, research, and biomarker measures, except for objective and self-reported measures of imbalance and symptoms of fatigue, posttraumatic stress, and depression. This study did not replicate the findings of previous studies, although differences in the populations included and the timing of assessments limit direct comparisons.

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