• Ibrahim Ileri, Funda Eren, Salim Neselioglu, Merve Hafızoglu, Didem Karaduman, Cansu Atbas, Zeynep Sahiner, Ayse Dikmeer, Cafer Balcı, Burcu Balam Dogu, Mustafa Cankurtaran, Ozcan Erel, and Meltem Gülhan Halil.
• Division of Geriatric Medicine, Department of Internal Medicine, Hacettepe University School of Medicine, Ankara, Turkey. ibrahimileri60@hotmail.com.
• Ir J Med Sci. 2024 Aug 1; 193 (4): 210921142109-2114.

BackgroundOxidative stress results from an imbalance between the induction of reactive oxygen species and the ability of cells to metabolize them. Numerous markers can be used to assess the level of oxidative stress. Thiol-disulfide homeostasis (TDH) and ischemia-modified albumin (IMA) are some of them. The aim of this study is to investigate the role of TDH and IMA, which are indicators of oxidative stress, in older patients with osteosarcopenia (OS).MethodsThe study was conducted cross-sectionally in a geriatrics outpatient clinic. Patients who applied to the outpatient clinic for three months were included in the study. Patients with acute infection, delirium, malignancy, severe liver, heart or kidney dysfunction and who did not give their consent for the study were excluded from the study. The study was conducted with 136 patients. Sarcopenia was diagnosed according to muscle ultrasonography (USG) and handgrip strength (HGS) results. Osteopenia/osteoporosis was diagnosed according to bone mineral densitometry (BMD) results. The combination of osteopenia/osteoporosis and sarcopenia was accepted as OS.ResultsNative thiol, total thiol value and nativethiol /totalthiol*100 values were significantly lower in the group with OS (respectively; value = 265 ± 53.8 standard deviation (SD) μmol/L, p =  ≤ 0.001; value = 295.33 ± 55.77 SD μmol/L, p = 0.001; value = 90.06 (2.8) interquartile ranges (IQR), p = 0.033). Disulfide/native thiol*100 and disulfide/total thiol*100 values were significantly higher in the group with OS (respectively; value = 5.5 (1.7) IQR, p = 0.033; value = 4.97 (1.4) IQR, p = 0.034).ConclusionIn our study, the role of oxidative stress in OS was demonstrated by using TDH as an oxidative stress parameter.© 2024. The Author(s), under exclusive licence to Royal Academy of Medicine in Ireland.

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