• Am. J. Med. · Mar 2017

    Trends in Incidence of Hospitalized Acute Myocardial Infarction in the Cardiovascular Research Network (CVRN).

    • Kristi Reynolds, Alan S Go, Thomas K Leong, Denise M Boudreau, Andrea E Cassidy-Bushrow, Stephen P Fortmann, Robert J Goldberg, Jerry H Gurwitz, David J Magid, Karen L Margolis, Catherine J McNeal, Katherine M Newton, Rachel Novotny, Charles P Quesenberry, Wayne D Rosamond, David H Smith, Jeffrey J VanWormer, Suma Vupputuri, Stephen C Waring, Marc S Williams, and Stephen Sidney.
    • Department of Research & Evaluation, Kaiser Permanente Southern California, Pasadena, Calif. Electronic address: Kristi.Reynolds@kp.org.
    • Am. J. Med. 2017 Mar 1; 130 (3): 317327317-327.

    BackgroundMonitoring trends in cardiovascular events can provide key insights into the effectiveness of prevention efforts. Leveraging data from electronic health records provides a unique opportunity to examine contemporary, community-based trends in acute myocardial infarction hospitalizations.MethodsWe examined trends in hospitalized acute myocardial infarction incidence among adults aged ≥25 years in 13 US health plans in the Cardiovascular Research Network. The first hospitalization per member for acute myocardial infarction overall and for ST-segment elevation myocardial infarction and non-ST-segment elevation myocardial infarction was identified by International Classification of Diseases, Ninth Revision, Clinical Modification primary discharge codes in each calendar year from 2000 through 2008. Age- and sex-adjusted incidence was calculated per 100,000 person-years using direct adjustment with 2000 US census data.ResultsBetween 2000 and 2008, we identified 125,435 acute myocardial infarction hospitalizations. Age- and sex-adjusted incidence rates (per 100,000 person-years) of acute myocardial infarction decreased an average 3.8%/y from 230.5 in 2000 to 168.6 in 2008. Incidence of ST-segment elevation myocardial infarction decreased 8.7%/y from 104.3 in 2000 to 51.7 in 2008, whereas incidence of non-ST-segment elevation myocardial infarction increased from 126.1 to 129.4 between 2000 and 2004 and then decreased thereafter to 116.8 in 2008. Age- and sex-specific incidence rates generally reflected similar patterns, with relatively larger decreases in ST-segment elevation myocardial infarction rates in women compared with men. As compared with 2000, the age-adjusted incidence of ST-segment elevation myocardial infarction in 2008 was 48% lower among men and 61% lower among women.Conclusions And RelevanceAmong a large, diverse, multicenter community-based insured population, there were significant decreases in incidence of hospitalized acute myocardial infarction and the more serious ST-segment elevation myocardial infarctions between 2000 and 2008. Decreases in ST-segment elevation myocardial infarctions were most pronounced among women. While ecologic in nature, these secular decreases likely reflect, at least in part, results of improvement in primary prevention efforts.Copyright © 2016 Elsevier Inc. All rights reserved.

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