• Andreas Leiherer, Axel Muendlein, Christoph H Saely, Elena Kinz, Eva M Brandtner, Peter Fraunberger, and Heinz Drexel.
• Vorarlberg Institute for Vascular Investigation and Treatment (VIVIT), Feldkirch, Austria Private University of the Principality of Liechtenstein, Triesen, Liechtenstein Medical Central Laboratories, Academic Teaching Hospital Feldkirch, Feldkirch, Austria Department of Medicine and Cardiology, Academic Teaching Hospital Feldkirch, Feldkirch, Austria Drexel University College of Medicine, Philadelphia, PA, USA.
• Medicine (Baltimore). 2017 Feb 1; 96 (5): e5798e5798.

AbstractUromodulin is the most abundant urine protein under physiological conditions. It has recently been described as a serum and plasma marker for kidney disease. Whether uromodulin is associated with impaired glucose metabolism is unknown.We therefore measured serum uromodulin and glucose traits in a cohort of 529 consecutively recruited patients.Serum uromodulin was significantly and inversely correlated with fasting plasma glucose (r = -0.161; P < 0.001), with plasma glucose 2 hours after an oral 75 g glucose challenge (r = -0.158; P = 0.001), and with HbA1c (r = -0.103; P = 0.018). A total of 146 (27.6%) of our patients had type 2 diabetes mellitus (T2DM). Analysis of covariance confirmed that T2DM was an independent determinant of serum uromodulin (F = 5.5, P = 0.020) after multivariate adjustment including hypertension and glomerular filtration rate. Prospectively, uromodulin was lowest in patients with T2DM at baseline, higher in initially nondiabetic subjects who developed diabetes during follow-up (FU) and highest among nondiabetic patients (147.7 ± 69.9 vs 164 ± 67 vs 179.9 ± 82.2 ng/mL, Ptrend < 0.001). Similar results were seen with respect to prediabetes (168.0 ± 81.2 vs 172.8 ± 66.3 vs 188.2 ± 74.0 ng/mL, P = 0.011).We conclude that serum uromodulin is significantly associated with impaired glucose metabolism and the development of prediabetes and diabetes.

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