• Am. J. Med. · Jul 2024

    Review

    Management of Clostridioides difficile infection: Diagnosis, Treatment, and Future Perspectives.

    • Michael Cymbal, Arjun Chatterjee, Brian Baggott, and Moises Auron.
    • Department of Internal Medicine, Cleveland Clinic, Cleveland, Ohio.
    • Am. J. Med. 2024 Jul 1; 137 (7): 571576571-576.

    AbstractClostridioides difficile infection is the most common healthcare-associated infection in the United States, with potential life-threatening complications and a significant impact on the costs of care. Antibiotic stewardship as well as discontinuation of chronic acid suppressive therapy are key for its prevention and treatment. Effective infection management requires appropriate interpretation of diagnostic tests, as well as the use of vancomycin and fidaxomicin as first-line treatment. Novel treatments such as Bezlotoxumab, fecal microbiota transplant, and live biotherapeutic products are proven effective in recurrent C. difficile infection and address dysbiosis.Copyright © 2024 The Authors. Published by Elsevier Inc. All rights reserved.

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