• Zhijun Xie, Huaxiang Wu, Xiaoqing Jing, Xiuyang Li, Yasong Li, Yongmei Han, Xiangfu Gao, Xiaopo Tang, Jing Sun, Yongshen Fan, and Chengping Wen.
• College of Basic Medical Science, Zhejiang Chinese Medical University Department of Rheumatism, The Second Affiliated Hospital of Zhejiang University Medical College Department of Rheumatism, Zhejiang Hospital Department of Public Health, Medical College, Zhejiang University Department of Rheumatism, Zhejiang People's Hospital Department of Rheumatism, Sir Run Run Shaw Hospital of Zhejiang University Medical College Department of Rheumatism, The First Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou Department of Rheumatism, Chinese Medical Academy Gate Hospital, Beijing Department of Rheumatism, The Second Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, P.R. China.
• Medicine (Baltimore). 2017 Mar 1; 96 (11): e6315e6315.

Trial DesignIn the double-blind, randomized, controlled trial, we aimed to evaluate the effects of compound tufuling oral liquid (CoTOL) on serum uric acid (sUA) levels and recurrence of acute gouty arthritis in intercritical and chronic gout treatment.MethodsA total of 210 patients with gout were screened from 8 hospitals to observe the sUA and acute gouty arthritis recurrence rate-reducing effects of CoTOL in intercritical and chronic gout during a 12-week treatment. We treated 139 and 71 patients with CoTOL and the placebo, respectively, and evaluated their sUA levels, acute gouty arthritis recurrence rate, and adverse events at week 0, 6, and 12.ResultsTwenty-five and 12 patients in the treatment and control groups, respectively, had interrupted treatments, whereas 114 and 59 cases, respectively, completed their treatments. At the end of the 12-week treatment, the average decrease in sUA was 74.26 (95% confidence interval [CI]: 56.74-91.77 μmol/L) and 28.81 μmol/L (95% CI: 4.91-52.71 μmol/L) in the treatment and control groups, respectively (P = 0.004). The average decrease rate of sUA was 12.76% (95% CI: 9.82%-15.70%) and 4.57% (95% CI: 0.42%-8.71%) in the treatment and control groups, respectively (P = 0.004), and the gouty arthritis recurrence rate of the treatment group was lower than that of the control group (from week 6 to 12, 21.93% and 50.88% in the treatment and control group, respectively, P < 0.001; from baseline to week 12, 38.5% and 63.16%, respectively, P = 0.003). Severe adverse events were not observed in either groups, and fewer leucopenia incidences were observed in the treatment group than those in the control group (3/139 vs. 7/71, respectively, P = 0.033).ConclusionCoTOL reduced sUA levels and effectively prevented acute arthritis recurrence in intercritical and chronic gout without serious adverse events.

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