• Yan Wang, Jin-Ping Li, Ying-Lun Song, and Qi-Huang Zhao.
• Department of Neurosurgery (Intensive Care Unit) Department of Neurosurgery, Beijing ChaoYang Hospital, Capital Medical University, Beijing, China.
• Medicine (Baltimore). 2017 Mar 1; 96 (13): e6458e6458.

ObjectiveTo assess the effect of intensive insulin therapy (IIT) for preventing postoperative infection in patients with traumatic brain injury (TBI).MethodsIn total, 88 patients with TBI were randomly divided into 2 groups, 44 in each group. One group (group ITT) received IIT and the other group (group CIT) received conventional insulin therapy (CIT). This study was conducted between February 2013 and January 2016. Outcomes included infection rate, mortality, and neurological outcome (measured by the Glasgow Outcome Scale [GOS]).ResultsA total of 81 patients completed the study. IIT showed greater efficacy than CIT, with a decreased infection rate in the IIT group compared to the CIT group (31.9% vs 52.3%, P = 0.03), and also a reduced duration of stay in intensive care unit (ICU) (IIT group, 4.5 ± 2.1 days vs CIT group, 5.7 ± 2.8 days, P = 0.02). In addition, a significant difference in scores on the GOS scale was observed between the 2 groups (P = 0.04). The mortality rates in hospital and at the 26-week follow-up were similar between the 2 groups.ConclusionIIT leads to a reduced infection rate, shorter stays in ICU, and improved neurological outcome.

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