• Yun Zhao, Ya Li, Li Wang, Xiao-Feng Li, Ci-Bo Huang, Guo-Chun Wang, Xue-Wu Zhang, Zhuo-Li Zhang, Xiao Zhang, Wei-Guo Xiao, Lie Dai, Yong-Fu Wang, Shao-Xian Hu, Hong-Bin Li, Lu Gong, Bin Liu, Ling-Yun Sun, Miao-Jia Zhang, Xuan Zhang, Yong-Zhe Li, De-Shun Du, Shun-Hua Zhang, Yuan-Yuan Sun, and Feng-Chun Zhang.
• From the Department of Rheumatology and Clinical Immunology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Key Laboratory of Rheumatology & Clinical Immunology, Ministry of Education, Beijing (YZ, YL, LW, XZ, Y-ZL, Y-YS, F-CZ); Department of Rheumatology and Immunology, Shanxi Medical University Second Hospital, Taiyuan (X-FL); Department of Rheumatology and Immunology, Beijing Hospital (C-BH); Department of Rheumatology and Immunology, China-Japan Friendship Hospital (G-CW); Department of Rheumatology and Immunology (X-WZ); Department of Rheumatology and Immunology, Peking University First Hospital, Beijing (ZZ); Department of Rheumatology and Immunology, Guangdong General Hospital, Guangdong Academy of Medical Sciences, Guangzhou (XZ); Department of Rheumatology and Clinical Immunology, The First Hospital, China Medical University, Shenyang (W-GX); Department of Rheumatology and Clinical Immunology, SUN Yat-sen Memorial Hospital of SUN Yat-sen University, Guangzhou (LD); Department of Rheumatology and Immunology, The First Affiliated Hospital of Baotou Medical College, Baotou (Y-FW); Department of Immunology and Rheumatology, Tongji Hospital, Tongji Medical College, Huazhong University of Science & Technology,Wuhan (S-XH); Department of Rheumatology and Clinical Immunology, Affiliated Hospital of Inner Mongolia Medical College, Hohhot (H-BL); Department of Rheumatology and Clinical Immunology, General Hospital of Tianjin Medical University, Tianjin (LG); Department of Rheumatology and Immunology, The Affiliated Hospital of Medical College Qingdao University, Qingdao (BL); Department of Rheumatology and Immunology, The Affiliated Drum Tower Hospital of Nanjing University Medical School (L-YS); Department of Rheumatology and Clinical Immunology, Jiangsu Provincial People's Hospital, Nanjing (M-JZ); Department of Stomatology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College (D-SD); Department of Ophthalmology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, People's Republic of China (S-HZ).
• Medicine (Baltimore). 2015 Apr 1; 94 (16): e667e667.

AbstractThe epidemiological characteristics of Sjögren syndrome (SS) are significantly varied in different countries. We conducted the present study to survey the epidemiological characteristics of primary SS in China. We recruited 483 primary SS patients from 16 Chinese medical centers nationwide from January 2009 to November 2011 and assessed salivary and lacrimal gland dysfunction, organ involvement, and autoimmunity in these patients. The cohort included 456 women and 27 men (ratio, 17:1; mean age at onset, 42 ± 11 years; median age at diagnosis, 49 years; range, 41-56 years). Male patients showed a lower frequency of xerophthalmia (37.0% vs 60.7%) and a higher frequency of arthritis (40.7% vs 16.4%). Young-onset patients showed a higher frequency of low C3 levels (57.7% vs 36.3%) and pancytopenia (22.2% vs 8.8%). Patients with systemic involvement had a higher frequency of immunoglobulin A (IgA) (39.4% vs 22.5%) and immunoglobulin M (IgM) (12.4% vs 37.9%). Patients with pulmonary involvement had a higher parotid enlargement (21.4% vs 10.2%), purpura (12.1% vs 5.7%) and higher anti-La/SS-B (61.7% vs 41.8%), immunoglobulin G (IgG) (80.7% vs 64.6%) and IgA (48.9% vs 30.6%) levels. Patients with anti-Ro/SSA antibodies had more frequent exocrine gland symptoms and some extraglandular symptoms and immunological alterations. Compared with previous studies performed in other countries, SS patients in China showed particular clinical manifestation, systemic involvement, and immunological alterations.

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