• Michael Krakau, Kathrin Gerbershagen, Ulrich Frost, Markus Hinzke, Michael Brockmann, Verena Schildgen, Axel Gomann, Volker Limmroth, Arno Dormann, and Oliver Schildgen.
• From the Kliniken der Stadt Köln gGmbH, Medizinische Klinik Holweide, Lehrkrankenhaus der Universität zu Köln, Köln, Germany (MK, AD); Kliniken der Stadt Köln gGmbH, Klinikum der Privaten Universität Witten/Herdecke mit Sitz in Köln, Neurologische Klinik, Köln, Germany (KG, UF, MH, VL, OS); Kliniken der Stadt Köln gGmbH, Klinikum der Privaten Universität Witten/Herdecke mit Sitz in Köln, Institut für Pathologie, Köln, Germany (MB, VS); and Kliniken der Stadt Köln gGmbH, Klinikum der Privaten Universität Witten/Herdecke mit Sitz in Köln, Radiologische Klinik, Köln, Germany (AG).
• Medicine (Baltimore). 2015 Oct 1; 94 (42): e1587e1587.

AbstractAlthough the human bocavirus (HBoV) is known since a decade, limited information about its pathogenesis is available due to the lack of an animal model. Thus, clinical cases and studies are the major source of novel information about the course of infection and the related pathophysiology.In this context, a clinical case of an adult patient suffering from severe HBoV-pneumonia is described that was associated with loss of consciousness followed by acute rib fracture and subsequent neurological disorder.Following initial global respiratory dysfunction the clinical respiratory symptoms recovered but the neurological symptoms maintained after weaning and intensive care in the stroke unit. During the initial phase, an acute active HBoV infection was confirmed by positive polymerase chain reactions from bronchoalveolar lavage fluid and serum.The case further demonstrates that HBoV can cause severe pneumonia, induce secondary disease also in adults, and may be associated with neurological symptoms as previously assumed.

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