• Francisco Artur Forte Oliveira, Clarissa Pessoa Fernandes Forte, SilvaPaulo Goberlânio de BarrosPGB, Camile B Lopes, Raquel Carvalho Montenegro, Ândrea Kely Campos Ribeiro Dos Santos, Carlos Roberto Martins Rodrigues Sobrinho, Mário Rogério Lima Mota, Fabrício Bitu Sousa, and AlvesAna Paula Negreiros NunesAPNN.
• From the Department of Stomatology and Oral Pathology, School of Dentistry, Federal University of Ceara, Fortaleza, Ceará (FAFO, CPF, PGBS, MRLM, FBS); Department of Oral Pathology, School of Dentistry, Federal University of Ceara, Fortaleza, Ceará (APNNA); Department of Clinical Medicine, School of Medicine, Federal University of Ceara, Fortaleza, Ceará (CRMRS); Laboratory of Human and Medical Genetics, Institute of Biological Sciences, Federal University of Pará, Belém, Pará, Brazil (CBL, AKCRS); Human Cytogenetics Laboratory, Institute of Biological Sciences, Federal University of Pará, Belém, Pará, Brazil (RCM).
• Medicine (Baltimore). 2015 Nov 1; 94 (47): e2067e2067.

AbstractStructural deficiencies and functional abnormalities of heart valves represent an important cause of cardiovascular morbidity and mortality, and a number of diseases, such as aortic stenosis, have been recently associated with infectious agents. This study aimed to analyze oral bacteria in dental plaque, saliva, and cardiac valves of patients with cardiovascular disease. Samples of supragingival plaque, subgingival plaque, saliva, and cardiac valve tissue were collected from 42 patients with heart valve disease. Molecular analysis of Streptococcus mutans, Prevotella intermedia, Porphyromonas gingivalis, and Treponema denticola was performed through real-time PCR. The micro-organism most frequently detected in heart valve samples was the S. mutans (89.3%), followed by P. intermedia (19.1%), P. gingivalis (4.2%), and T. denticola (2.1%). The mean decayed, missing, filled teeth (DMFT) was 26.4 ± 6.9 (mean ± SD), and according to the highest score of periodontal disease observed for each patient, periodontal pockets > 4 mm and dental calculus were detected in 43.4% and 34.7% of patients, respectively. In conclusion, oral bacteria, especially S. mutans, were found in the cardiac valve samples of patients with a high rate of caries and gingivitis/periodontitis.

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