• Wen-Yuan Lin, Cheng-Yuan Peng, Cheng-Chieh Lin, Lance E Davidson, F Xavier Pi-Sunyer, Pei-Kun Sung, and Kuo-Chin Huang.
• From the Department of Family Medicine (W-YL, C-CL); Department of Internal Medicine, China Medical University Hospital, Taichung, Taiwan (C-YP); School of Medicine, College of Medicine, China Medical University, Taichung, Taiwan(W-YL, C-CL, C-YP); Department of Family Medicine, National Taiwan University Hospital, Taipei, Taiwan (W-YL, K-CH); Institute of Health Care Administration, College of Health Science, Asia University, Taichung, Taiwan (C-CL); MJ Health Screening Center, Taipei, Taiwan (P-KS); College of Life Sciences, Brigham Young University, Utah, USA (LED); and New York Presbyterian Hospital, Columbia University, New York, USA (FXP-S).
• Medicine (Baltimore). 2016 Jan 1; 95 (2): e2162e2162.

AbstractBoth obesity and hepatitis B virus (HBV) infection increase the risk of death. We investigate the association between general and central obesity and all-cause mortality among adult Taiwanese HBV versus non-HBV carriers.A total of 19,850 HBV carriers and non-hepatitis C virus (HCV) carriers, aged 20 years and older at enrollment in 1998 to 1999 in Taiwan, were matched to 79,400 non-HBV and non-HCV carriers (1:4). Cox proportional-hazards models were used to estimate the relative risks for all-cause mortality during a maximum follow-up period of 10 years. Four obesity-related anthropometric indices-body mass index (BMI), waist circumference, waist-to-hip ratio, and waist-to-height ratio-were the main variables of interest.During the follow-up period, 628 and 2366 participants died among HBV and non-HBV carriers, respectively. Both underweight and general obesity were associated with an increased risk of death. The highest risk of all-cause death in relation to BMI was found in the HBV carriers with underweight (BMI <18.5 kg/m2) and non-HBV carriers with obesity (BMI ≥30 kg/m2). The lowest risks of all-cause death in relation to abdominal adiposity were found at the third quartiles of waist circumference, waist-to-hip ratio, and waist-to-height ratio among HBV carriers, but in the second quartiles among non-HBV carriers. For those with pre-existing liver disease among HBV carriers, patients with underweight have higher risk of death than those with obesity.Hepatitis B virus carriers with underweight have higher risk of death than non-HBV carriers. HBV carriers with mild abdominal obesity have the lowest risk of death, but not in the non-HBV carriers.

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