• Etienne Ghrenassia, Arsene Mekinian, Catherine Chapelon-Albric, Pierre Levy, Jacques Cosnes, Pascal Sève, Guillaume Lefèvre, Robin Dhôte, David Launay, Virginie Prendki, Sandrine Morell-Dubois, Danielle Sadoun, Anas Mehdaoui, Michael Soussan, Anne Bourrier, Laure Ricard, Robert Benamouzig, Dominique Valeyre, Olivier Fain, and and the Groupe Sarcoïdose Francophone.
• AP-HP, Hôpital Saint-Antoine, Sorbonne Universités, UPMC Université Paris 06, service de médecine interne and Inflammation-Immunopathology-Biotherapy Department (DHU i2B) APHP, Hôpital Pitié-Salpétrière, Sorbonne Universités, UPMC Université Paris 06, service de médecine interne APHP, Hôpital Tenon, Sorbonne Universités, UPMC Université Paris 06, Public health department APHP, Hôpital Saint-Antoine, Sorbonne Universités, UPMC Université Paris 06, service de gastro-entérologie, Paris Hôpital de la Croix-Rousse, Hospices Civils de Lyon, department of internal medicine, F-Lyon. University Claude Bernard Lyon 1, F-69100, Villeurbanne. Hôpital Claude Huriez, service de médecine interne, Lille, France APHP, Hôpital Avicenne, service de médecine interne, université Paris 13, Bobigny, France Department of internal medicine, Division of internal medicine and rehabilitation, rehabilitation and geriatrics, Geneva University Hospitals and University of Geneva, Geneva, Switzerland APHP, Hôpital Avicenne, Université Paris 13, service de pneumologie, Bobigny Hôpital Evreux, service de pneumologie, Evreux APHP, Hôpital Avicenne, Université Paris 13, service de médecine nucléaire APHP, Hôpital Avicenne, Université Paris 13, service de gastro-entérologie, Bobigny, France .
• Medicine (Baltimore). 2016 Jul 1; 95 (29): e4279e4279.

AbstractDigestive tract sarcoidosis (DTS) is rare and case-series are lacking. In this retrospective case-control study, we aimed to compare the characteristics, outcome, and treatment of patients with DTS, nondigestive tract sarcoidosis (NDTS), and Crohn disease.We included cases of confirmed sarcoidosis, symptomatic digestive tract involvement, and noncaseating granuloma in any digestive tract. Each case was compared with 2 controls with sarcoidoisis without digestive tract involvement and 4 with Crohn disease.We compared 25 cases of DTS to 50 controls with NDTS and 100 controls with Crohn disease. The major digestive clinical features were abdominal pain (56%), weight loss (52%), nausea/vomiting (48%), diarrhea (32%), and digestive bleeding (28%). On endoscopy of DTS, macroscopic lesions were observed in the esophagus (9%), stomach (78%), duodenum (9%), colon, (25%) and rectum (19%). As compared with NDTS, DTS was associated with weight loss (odds ratio [OR] 5.8; 95% confidence interval [CI] 1.44-23.3) and the absence of thoracic adenopathy (OR 5.0; 95% CI 1.03-25). As compared with Crohn disease, DTS was associated with Afro-Caribbean origin (OR 27; 95% CI 3.6-204) and the absence of ileum or colon macroscopic lesions (OR 62.5; 95% CI 10.3-500). On the last follow-up, patients with DTS showed no need for surgery (versus 31% for patients with Crohn disease; P = 0.0013), and clinical digestive remission was frequent (76% vs. 35% for patients with Crohn disease; P = 0.0002).The differential diagnosis with Crohn disease could be an issue with DTS. Nevertheless, the 2 diseases often have different clinical presentation and outcome.

29 keywords...

hide…