• Asmat Shaheen, Rubina Nazli, Sadia Fatima, Roshan Ali, Ihsanullah Khan, and Salim Khattak.
• Dr. Asmat Shaheen, BDS, M.Phil. Assistant Professor of Biochemistry, Institute of Medical Sciences, Khyber Medical University (KMU), Kohat, Pakistan.
• Pak J Med Sci. 2016 Nov 1; 32 (6): 141914241419-1424.

Background And ObjectivesHypertensive disorder in pregnancy is the significant disease that badly affects the maternal and fetal prognosis and lead to higher mortality and morbidity in the prenatal period. Visfatin, potentially a new adipokine has emerged having high contribution in pathogenesis of pre-eclampsia. The objective of the study was to find the level of Visfatin in pregnancy induced hypertension and normal pregnant women.MethodsThis study was carried out in tertiary care hospitals, Peshawar from March-October 2014. A total of 234 pregnant women (gestational age >20 weeks) were included in the study with distribution as Preeclampsia (PE=86), Eclampsia (E=74) and control (N=74). Blood was taken for measuring Visfatin level by Enzyme Linked Immunosorbent Assay (ELISA) technique. SPSS version 19 was used for statistical analysis. Student's t test was performed to evaluate the mean differences in patients and control.ResultsSerum level of visfatin was significantly higher in pregnancy induced hypertension when compared with control (P value<0.001).: Comparisons of mean value of visfatin with age group of 21-40 years, body mass index (BMI), primary parous and parity 2-4, gestational age of >36 weeks and both systolic and diastolic blood pressure were highly significant in pregnancy induced hypertension when compared with control (p value<0.001).ConclusionPregnancy induced hypertensive women showed increased level of serum Visfatin than normal pregnant women.

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