• Pak J Med Sci · Mar 2024

    Effects of combined sintilimab and chemotherapy on progression-free survival and overall survival in osteosarcoma patients with metastasis.

    • Fan Li, De-Bao Zhang, Yue Ma, Yang Song, and Xian-Liang Duan.
    • Fan Li, Department of Orthopaedics, Affiliated Hospital of Beihua University, 132011 Jilin, P. R. China.
    • Pak J Med Sci. 2024 Mar 1; 40 (4): 648651648-651.

    ObjectiveTo explore the safety and efficacy of metastatic osteosarcoma treatment with combined sintilimab injection and chemotherapy.MethodsWe performed a retrospective analysis of 32 patients with metastatic osteosarcoma admitted to the Affiliated Hospital of Beihua University between January 2019 and June 2020. The sample was divided into an observation group, treated with sintilimab injection combined with chemotherapy (n= 16) and a control group, treated with chemotherapy (n = 16). Clinical efficacy and adverse reactions were compared between the two groups.ResultsThe overall response rates were 68.75% in the observation group and 31.25% in the control group (p < 0.05). The incidences of adverse reactions were 56.25% in the observation group and 81.25% in the control group. This was not a significant difference. In the observation group, the progression-free survival time was 8.13 ± 2.50 months, and the overall survival time was 22.75 ± 4.95 months. These were both significantly longer than the respective 6.44 ± 1.93 months and 19.69 ± 2.68 months in the control group (p < 0.05).ConclusionThe treatment of metastatic osteosarcoma with combined sintilimab injection and chemotherapy was found to prolong progression-free survival and overall survival time without increasing the incidence of adverse reactions.Copyright: © Pakistan Journal of Medical Sciences.

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